Dedicated to San Juan Nepomuceno, the Church of Anini-y in Antique dates back to the Spanish colonial era in the Philippines.

It is believed the first town church was built way back between 1630 and 1638, when Anini-y was still a visita first of Antique and then Dao, by priests assigned to minister to the small local population.

Although the foundations of the first structure still existed when the second church was erected close by around 1845, there were no records as who built it, according to Fr. Pedro Galende in his book Angels of Stone.

The second church was destroyed during World War II.

Galende said the current one is a full restoration of the Anini-y Church made of masonry that Fr. Jeronimo Vaquerin started building close to 1900.

Except for a large arch near the main altar, the third Anini-y Church was basically finished in 1898. Galende described it as being made of coral stones, with one main nave and transept, and complemented by a three-story belltower that rose 25 meters high.

Anini-y became an independent parish through a decree issued on December 20, 1861 but took effect only on March 22, 1862 when Gov. Gen. Jose Lemery signed the order of separation. It had been administered by Augustinians since 1581.